Police arrested nine men following an affray and stabbing in Hoppers Crossing during the early hours of Saturday, November 23.
Police said emergency services were called to Mossfiel Drive, where they found a 23-year-old man with injuries about 3.40am.
The man was taken to hospital with life-threatening injuries and remains in a critical but stable condition, according to police.
Police said nine men were arrested at the scene.
Police are also investigating an incident where another man self-presented a hospital in Werribee with suspected stab wounds about 4am, with the location of the stabbing yet to be determined.
The 16-year-old boy arrived at hospital with serious injuries in a black Mazda CX9, according to police.
Police said investigations are ongoing and that they believed the incidents were targeted at this stage.
Detectives are working to establish whether the two incidents are linked, according to police.
Witnesses and anyone with CCTV/dashcam footage or information are urged to contact Crime Stoppers on 1800 333 000 or www.crimestoppersvic.com.au